GeneAb™

SRRM4/nSR100

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$210.00

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Cat. No.

IHC413-100

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Description

Serine/Arginine Repetitive Matrix 4 (SRRM4), also known as nSR100, is a vertebrate- and neural-specific Ser/Arg repeat-related protein that acts in the brain as a key regulator of alternative splicing. nSR100 has been identified as an activator of the small cell lung cancer-specific isoform of RE1-silencing transcription factor. The protein is involved in the progression of neuroendocrine prostate cancer, an aggressive subtype of castration-resistant prostate cancer, and has been suggested as a potential therapeutic target. A correlation has been made between underexpression of the SRRM4 protein and autism spectrum disorders.

Specifications

Clone IHC413
Source Mouse Monoclonal
Positive Control Cerebellum
Dilution Range 1:100 - 1:200

References

  1. Kelsey R. Nat Rev Urol. 2016; 13:371.
  2. Li Y, et al. Eur Urol. 2017; 71:68-78.
  3. Shimojo M, et al. Mol Cancer Res. 2013; 11:1258-68.
  4. Quesnel-Vallières M, et al. Genes Dev. 2015; 29:746-59.
  5. Quesnel-Vallières M, et al. Mol Cell. 2016; 64:1023-34.