Smoothelin is a protein found explicitly in the cytoskeletal component of differentiated (contractile) smooth muscle cells, while being absent from myofibroblasts, myoepithelial cells, and skeletal and cardiac muscle. Anti-Smoothelin is often used as an aid in staging bladder carcinoma, as overexpression of the smoothelin protein is characteristic of muscularis propria invasion, while negative or weak staining is indicative of muscularis mucosae and the non-invasive form of the cancer. Anti-Smoothelin is also useful in differentiating benign smooth muscle tumours from malignant smooth muscle tumours.

• IHC663-Smoothelin Datasheet-IVD

• MSDS

CLONE:
IHC663

ISOTYPE:


HOST SPECIES:
Mouse

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Bladder, Smooth muscle

DILUTION RANGE:


INTENDED USE/REG. STATUS:
IVD