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T-bet is a transcription factor present in CD4+ T-cells. Anti-T-bet stains mature T-lymphocytes, but is scarcely present in T helper cells. Nuclear staining is observed in the interfollicular T-cell zone of reactive lymphoid tissue (tonsil, lymph node, and spleen) and absent in germinal centers or mantle or marginal zones. Anti-T-bet also stains certain B-cell lymphoproliferative disorders, such as precursor B-cell lymphoblastic leukemia and lymphoblastic lymphoma, and B-cell neoplasms from mature B-cells, marginal zone lymphoma, and hairy cell leukemia. Anti-T-bet is useful for identifying B-cell and T-cell lymphoproliferative disorders, as it does not stain B-cell neoplasms from the pre-germinal center or germinal center B-cells, such as mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphoma.
  • References
    1. Szabo SJ, et al. Cell. 2000; 100:665-9.
    2. Zhang WX, et al. Genomics. 2001; 70:41-8.
    3. Johrens K, et al. Am J Surg Pathol. 2007; 31:1181-5.
    4. Atayar C, et al. Am J Pathol. 2005; 166:127-34.
    5. Dorfman DM, et al. Am J Clin Pathol. 2004; 122:292-7.
    6. Harashima A, et al. Leuk Res. 2005; 29:841-8.
    7. Marafioti T, et al. Am J Pathol. 2003; 162:861-71.


Clone IHC670
Source Mouse Monoclonal
Positive Control Tonsil, Hairy Cell Leukemia
Dilution Range 1:100 - 1:400