GeneAb™

TFE3

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$250.00

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Cat. No.

IHC672-100

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Description

Transcription Factor E3 (TFE3) is a transcription factor that binds to the MUE3-type E-box sequences involved in TGF-β signalling. Anti-TFE3 staining is the most sensitive and specific indicator of Xp11 translocation renal cell carcinomas. Since alveolar soft part sarcoma (ASPS) is characterized by a specific chromosomal rearrangement resulting in a chimeric transcription factor (ASPSCR1-TFE3), this TFE3 IVD antibody is also a useful diagnostic tool for recognizing ASPS.

Specifications

Clone IHC672
Source Mouse Monoclonal
Positive Control Testes, Melanoma, Xp11.2 Translocation Renal Cell Carcinoma
Dilution Range 1:100 - 1:200

References

  1. Argani P, et al. Am J Clin Pathol. 2006; 126:332-4.
  2. Argani P, et al. Am J Surg Pathol. 2003; 27:750-61.
  3. Lazar AJ, et al. Histopathology. 2009; 55:750-5.