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GeneAb™

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Description

T-cell-restricted Intracellular Antigen-1 (TIA1) is an RNA-binding protein involved in apoptosis, which is present in natural killer cells and cytotoxic T cells. Anti-TIA1 stains hairy cell leukemia, large granular lymphocyte (LGL) leukemia, and T-cell lymphoma. As overexpression of TIA1 is characteristic of LGL leukemia and decreased levels of TIA1 is indicative of T-cell lymphocytosis and other T-cell diseases, Anti-TIA1 may be useful in distinguishing between these diseases. TIA1 could also be a useful marker for identifying tumor-infiltrating lymphocytes and understanding the immune response to cancers.

References

1. Dukers DF, et al. J Clin Pathol. 1999; 52:129-36.
2. Kanavaros P, et al. Anticancer Res. 1999; 19:1209-16.