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Description

Thyroglobulin is a precursor to the thyroid hormones T4 and T3 and is present in the thyroid follicular cells. Nearly all thyroid follicular carcinomas stain for thyroglobulin and sometimes produce a focal staining pattern. Conversely, poorly differentiated carcinomas and non-thyroid adenocarcinomas do not stain for thyroglobulin, therefore this Thyroglobulin IVD antibody is a useful diagnostic tool for recognizing papillary and follicular thyroid carcinomas. A panel of Anti-Thyroglobulin and Anti-Calcitonin is useful for identifying medullary thyroid carcinomas, whereas a panel of Anti-Thyroglobulin and Anti-TTF1 is useful for distinguishing between primary thyroid and lung neoplasms.

References

1. Bellet D, et al. J Clin Endocrin Metab. 1983; 56:530-3.
2. Heffess CS, et al. Cancer. 2002; 95:1869-78.
3. Bejarano PA, et al. Appl Immunohistochem Mol Morphol. 2000; 8:189-94.
4. Judkins AR, et al. Hum Pathol. 1999; 30:1373-6.
5. Hammer SP. Hum Pathol. 1998; 29:1393-402.