GeneAb™

Uroplakin III

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$115.00

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Cat. No.

IHC681-100

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Description

Uroplakin III is a transmembrane protein that is a differentiation product of urothelial cells. Uroplakin III is present on non-neoplastic mammalian urothelium at the luminal plasmalemma of superficial umbrella cells, producing complexes of 16nm particles. Anti-Uroplakin III in useful for recognizing metastatic carcinomas of urothelial origin, as many urothelial carcinomas stain positively, while several non-urothelial carcinomas do not react. Recent studies also suggest that Uroplakin III is an indicator of the malignant potential, rather than the grade of the tumor.

Specifications

Clone IHC681
Source Mouse Monoclonal
Positive Control Bladder
Dilution Range 1:100 - 1:200

References

  1. Badalament RA, et al. J Urol. 1990; 144:859–63.
  2. Hall MC, et al. Urology. 1998; 52 :594–601.
  3. Logani S, et al. Am J Surg Pathol. 2003; 27:1434-41.
  4. Moll R, et al. Am J Pathol. 1995; 147:1383–97.
  5. Ohtsuka Y, et al. BJU Int. 2006; 97:1322-6.
  6. Olsburgh J, et al. J Pathol. 2003; 199:41–9.