GeneAb™

c-Myc

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$190.00

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Cat. No.

IHC548-100

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Description

c-Myc is a phosphoprotein involved with cell proliferation and differentiation. It is a useful marker for differentiation between Burkitt Lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) since, despite morphologically similarities between the two B-cell lymphomas Anti-c-Myc stains all BL and only a few DLBCL cases. A panel of antibodies against c-Myc, CD10, BCL2, and Ki-67 is useful for cases where MYC FISH analysis is warranted or can be omitted. Nuclear c-Myc overexpression is common in luminal cells of prostate intraepithelial neoplasia, many primary carcinomas, and metastatic disease.

Specifications

Clone IHC548
Source Mouse Monoclonal
Positive Control Breast Carcinoma
Dilution Range 1:100 - 1:200

References

  1. Green TM, et al. Am J Surg Pathol. 2012; 36:612-619.
  2. Aukema SM, et al. Blood. 2011l 117:2319-31.
  3. Gurel B, et al. Mod Pathol. 2008; 21:1156-67.