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GeneAb™

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Description

The human Equilibrative Nucleoside Transporter 1 (hENT1) mediates the cellular uptake of physiologic nucleosides, including adenosine, as well as many anti-cancer drugs including gemcitabine, cytarabine, and decitabine. De ciency of hENT1 can lead to resistance of such drugs, and the abundance of hENT1 protein in the plasma membrane is a major indicator of the e ciency and clinical outcome of these anti-cancer nucleosides.

References

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3. Sundaram M, et al. J Biol Chem. 2001; 276:45270-5.
4. Borbath I, et al. Eur J Cancer. 2012; 48:990-6.
5. Greenhalf W, et al. J Natl Cancer Inst. 2014; 106:djt347.
6. Wu L, et al. J Transl Med. 2016; 14:66.