GeneAb™

p21

(In the pipeline)

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Cat. No.

IHC021-100

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Description

p21, also known as p21Cip1 , p21Waf1, cyclin-dependent kinase inhibitor 1, or CDK-interacting protein 1, functions to regulate cell cycle progression at G1 by inhibiting the activity of Cyclin-CDK2 or -CDK4 complexes. This cyclin-dependent kinase inhibitor is expressed in all adult human tissues, and decreased expression of p21 is linked to poor prognosis in a number of carcinomas including gastric carcinoma, non-small cell lung carcinoma and thyroid carcinoma. p21 is also associated with favourable prognosis in several tumors.
  • References
    1. Winters ZE, et al. Eur J Cancer. 2001; 37:2405-12.
    2. Zhou BP, et al. Nat Cell Biol. 2001; 3:245-52.
    3. Winters ZE, et al. Breast Cancer Res. 2003; 5:R242-9.
    4. Dolezalova D, et al. Stem Cells. 2012; 7:1362-72.
    5. Almond JB, et al. Leukemia. 2002; 16:433-43.
    6. Gartel AL, et al. Cancer Res. 2005; 65:3980-5.
    7. Tamura M, et al. Ann Thorac Cardiovasc Surg. 2007; 13:9-14.

Specifications

Clone IHC021
Source Mouse Monoclonal
Positive Control Colon
Dilution Range 1:50-1:200

Literature