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Description

p27, also known as p27Kip1, is a cyclin-dependent kinase inhibitor that binds to and inhibits cyclin-dependent kinases, thereby regulating progression from G1 to S phase. Decreased expression of p27 is linked to poor prognosis in renal-cell carcinoma, colon carcinoma, small breast carcinomas, non-small-cell lung carcinoma, hepatocellular carcinoma, multiple myeloma, lymph node metastases in papillary carcinoma of the thyroid, and is associated with a more aggressive phenotype of carcinoma in the cervix.

References

1. Lloyd RV, et al. Am J Pathol. 1999; 154:313-23.
2. Migita T, et al. Cancer. 2002; 94:973-9.
3. Haitel A, et al. Urology. 2001; 58:477-81.
4. Esposito V, et al. Cancer Res. 1997; 57:3381-5.
5. Tan P, et al. Cancer Res. 1997; 57:1259-63
6. Khoo ML, et al. J Clin Endocrinol Metab. 2002; 87:1814-8.
7. Huang LW, et al. Gynecol Oncol. 2002; 85:524-8.
8. Ribal MJ, et al. Anticancer Res. 2003; 23:5101-6.
9. Khoo ML, et al. Arch Otolaryngol Head Neck Surg. 2002; 128:253-7.
10. Freedland SJ, et al. Urology. 2003; 61:1187-92.
11. Armengol C, et al. J Hepatol. 2003; 38:591-7.