GeneAb™

p504s

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Cat. No.

IHC504-100

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Description

p504s, also known as α-methylacyl coenzyme A racemase (AMACR), is an enzyme localized in the peroxisome and mitochondria, which functions in β-oxidation of branched chain fatty acids, as well as bile synthesis. AMACR has been clinically indicated as a tissue biomarker for prostate cancer and colorectal cancer, as well as high-grade prostatic intraepithelial neoplasia, a precursor lesion of prostate cancer. p504s overexpression has also been detected in a number of other cancers including ovarian, breast, bladder, lung, and renal cell carcinomas, lymphoma, and melanoma.
  • References
    1. Ferdinandusse S, et al. J Lipid Res. 2000; 41:1890-6.
    2. Xu J, et al. Cancer Res. 2000; 60:1677-82.
    3. Rubin MA, et al. JAMA. 2002; 287:1662-70.
    4. Luo J, et al. Cancer Res. 2002; 62:2220-6.
    5. Zhou M, et al. Am J Surg Pathol. 2002; 26:926-31.
    6. Wu CL, et al. Hum Pathol. 2004; 35:1008-13.

Specifications

Clone IHC504
Source Mouse Monoclonal
Positive Control Prostate Carcinoma
Dilution Range 1:50-1:200

Literature