GeneAb™

p57kip2

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$135.00

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Cat. No.

IHC057-100

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Description

p57kip2, also known as p57, is a tumor suppressor protein that causes cell cycle arrest at G1 by binding G1 cyclin-CDK complexes. The p57kip2 gene is a potential tumor suppressor target as the gene is located in a chromosomal region implicated in sporadic cancers, Wilms' tumor, and Beckwith Wiedemann syndrome. Anti-p57kip2 labels many cytotrophoblast nuclei and stromal cells in normal placenta, and is useful in differentiating between complete hydatidiform mole and partial hydatidiform mole or hydropic abortion.

Specifications

Clone IHC057
Source Mouse Monoclonal
Positive Control Placenta
Dilution Range 1:100 - 1:200

References

  1. Hatada I, et al. Hum Mol Genet. 1996; 5:783-8.
  2. Overall ML, et al. Genes Chromosomes Cancer. 1996; 17:56-9.
  3. Kihara M, et al. J Reprod Med. 2005; 50:307-12.
  4. Romaguera RL, et al. Fetal Pediatr Pathol. 2004; 23:181-90.
  5. Marjoniemi VM. Pathology. 2004; 36:109-19.
  6. Jun SY, et al. Histopathology. 2003; 43:17-25.