p57 kip2

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p57kip2, also known as p57, is a tumor suppressor protein that causes cell cycle arrest at G1 by binding G1 cyclin-CDK complexes. The p57kip2 gene is a potential tumor suppressor target as the gene is located in a chromosomal region implicated in sporadic cancers, Wilms' tumor, and Beckwith Wiedemann syndrome. Anti-p57kip2 labels many cytotrophoblast nuclei and stromal cells in normal placenta, and is useful in differentiating between complete hydatidiform mole and partial hydatidiform mole or hydropic abortion.
  • References
    1. Hatada I, et al. Hum Mol Genet. 1996; 5:783-8.
    2. Overall ML, et al. Genes Chromosomes Cancer. 1996; 17:56-9.
    3. Kihara M, et al. J Reprod Med. 2005; 50:307-12.
    4. Romaguera RL, et al. Fetal Pediatr Pathol. 2004; 23:181-90.
    5. Marjoniemi VM. Pathology. 2004; 36:109-19.
    6. Jun SY, et al. Histopathology. 2003; 43:17-25.


Clone IHC057
Source Mouse Monoclonal
Positive Control Placenta
Dilution Range 1:100 - 1:400