GeneAb™

p63

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Cat. No.

IHC063-100

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Description

p63 is a tumor suppressor protein that is very similar to p53 in structure and function, while being homologous to p73. p63 is important in development and differentiation, and has been identified as a useful marker for distinguishing between lung squamous cell carcinomas and adenocarcinomas. Anti-p63 is also used to differentiate between benign and malignant prostate and breast lesions, due to its labeling of the nuclei of myoepithelial cells in both tissue types.
  • References
    1. Yang A, et al. Mol Cell. 1998; 2:305-16.
    2. Signoretti S, et al. Am J Pathol. 2000; 157:1769-75.
    3. Yang A, et al. Nature. 1999; 398:714-8.
    4. Barbareschi M, et al. Am J Surg Pathol. 2001; 25:1054-60.
    5. Werling RW, et al. Am J Surg Pathol. 2003; 27:82-90.
    6. Rajal B Shah, et al. Am J Surg Pathol. 2002; 26:1161-8.
    7. Iacono ML, et al. J Thorac Oncol. 2011; 6:473-81.
    8. Mukhopadhyay S, et al. Am J Surg Pathol. 2011; 35:15-25.
    9. Conde E, et al. PLoS One. 2010; 5:e12209.
    10. Uke M, et al. Cytopathology. 2010; 21:56-63.

Specifications

Clone IHC063
Source Mouse Monoclonal
Positive Control Skin, Squamous Cell Carcinoma, Prostate
Dilution Range 1:50-1:200

Literature