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p63 is a tumor suppressor protein that is very similar to p53 in structure and function, while being homologous to p73. p63 is important in development and differentiation, and has been identified as a useful marker for distinguishing between lung squamous cell carcinomas and adenocarcinomas. Anti-p63 is also used to differentiate between benign and malignant prostate and breast lesions, due to its labeling of the nuclei of myoepithelial cells in both tissue types.
  • References
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    7. Iacono ML, et al. J Thorac Oncol. 2011; 6:473-81.
    8. Mukhopadhyay S, et al. Am J Surg Pathol. 2011; 35:15-25.
    9. Conde E, et al. PLoS One. 2010; 5:e12209.
    10. Uke M, et al. Cytopathology. 2010; 21:56-63.


Clone IHC063
Source Mouse Monoclonal
Positive Control Skin, Squamous Cell Carcinoma, Prostate
Dilution Range 1:100 - 1:400